Gene: LIN28A

Alternate names for this Gene: CSDD1|LIN-28|LIN28|ZCCHC1|lin-28A

Gene Summary: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.11

Description of this Gene: lin-28 homolog A

Type of Gene: protein-coding

rs7532866 in LIN28A gene and Body Height PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs7532866 in LIN28A gene and Height PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs6694351 in LIN28A gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.