Gene: LIPF

Alternate names for this Gene: GL|HGL|HLAL

Gene Summary: This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q23.31

Description of this Gene: lipase F, gastric type

Type of Gene: protein-coding

rs6586145 in LIPF gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs17286937 in LIPF gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.