Gene: LMO1

Alternate names for this Gene: RBTN1|RHOM1|TTG1

Gene Summary: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: LIM domain only 1

Type of Gene: protein-coding

Gene: LOC105376536

Alternate names for this Gene:

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rs4758317 in LMO1;LOC105376536 gene and Alcohol consumption PMID 23743675 2013 A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.

rs2168101 in LMO1;LOC105376536 gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

rs2168101 in LMO1;LOC105376536 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2168101 in LMO1;LOC105376536 gene and Neuroblastoma PMID 28545128 2017 Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.