Gene: LOC105371475

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: NOS1AP

Alternate names for this Gene: 6330408P19Rik|CAPON

Gene Summary: This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 1

Location in Chromosome : 1q23.3

Description of this Gene: nitric oxide synthase 1 adaptor protein

Type of Gene: protein-coding

rs10494366 in LOC105371475;NOS1AP gene and QT interval feature (observable entity) PMID 16648850 2006 A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 20062063 2010 Several common variants modulate heart rate, PR interval and QRS duration.

PMID 19305408 2009 Common variants at ten loci influence QT interval duration in the QTGEN Study.

PMID 23166209 2012 Impact of ancestry and common genetic variants on QT interval in African Americans.

rs1337068 in LOC105371475;NOS1AP gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs11805598 in LOC105371475;NOS1AP gene and White Blood Cell Count procedure PMID 21738479 2011 Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).