Gene: LOC105373868

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: FN1

Alternate names for this Gene: CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF

Gene Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Gene is located in Chromosome: 2

Location in Chromosome : 2q35

Description of this Gene: fibronectin 1

Type of Gene: protein-coding

rs1250258 in LOC105373868;FN1 gene and Endometriosis PMID 28333195 2017 Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.

rs1250258 in LOC105373868;FN1 gene and Fibronectin measurement PMID 28240269 2017 Connecting genetic risk to disease end points through the human blood plasma proteome.

rs1250258 in LOC105373868;FN1 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.