Gene: LOC105378867

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: DPYD

Alternate names for this Gene: DHP|DHPDHASE|DPD

Gene Summary: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p21.3

Description of this Gene: dihydropyrimidine dehydrogenase

Type of Gene: protein-coding

rs773499329 in LOC105378867;DPYD gene and Dihydropyrimidine Dehydrogenase Deficiency PMID 22353294 2012 Dual diagnosis of dihydropyrimidine dehydrogenase deficiency and GM₁ gangliosidosis.

rs11165851 in LOC105378867;DPYD gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs12047563 in LOC105378867;DPYD gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.