Gene: LRP1B

Alternate names for this Gene: LRP-1B|LRP-DIT|LRPDIT

Gene Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer.

Gene is located in Chromosome: 2

Location in Chromosome : 2q22.1-q22.2

Description of this Gene: LDL receptor related protein 1B

Type of Gene: protein-coding

rs41497646 in LRP1B gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1882642 in LRP1B gene and Adverse effects, not elsewhere classified PMID 30420678 2019 Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records.

rs12472911 in LRP1B gene and Age at menarche PMID 25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

PMID 21102462 2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12474609 in LRP1B gene and Aging PMID 19367585 2010 A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis.

rs13396415 in LRP1B gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs113533135 in LRP1B gene and Calcification of coronary artery PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs142320277 in LRP1B gene and Childhood asthma PMID 29551627 2018 Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

rs11895588 in LRP1B gene and Congenital Heart Defects PMID 28468790 2017 Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects.

rs142320277 in LRP1B gene and Cortisol Measurement PMID 29551627 2018 Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

rs113533135 in LRP1B gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs182518743 in LRP1B gene and Glomerular Filtration Rate PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs643684 in LRP1B gene and Influenza due to Influenza A virus subtype H1N1 PMID 26379185 2015 No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

rs13034371 in LRP1B gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs17515225 in LRP1B gene and Motion Sickness PMID 25628336 2015 Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.

rs75988504 in LRP1B gene and Prostate carcinoma PMID 31095341 2020 Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.

rs41497646 in LRP1B gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs77609760 in LRP1B gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs4954702 in LRP1B gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs4954702 in LRP1B gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs1033284 in LRP1B gene and Systolic Pressure PMID 25189868 2015 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

rs13013614 in LRP1B gene and Uveal melanoma PMID 31626034 2020 Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.

rs13007371 in LRP1B gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.