Gene: LYZ

Alternate names for this Gene: LYZF1|LZM

Gene Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.

Gene is located in Chromosome: 12

Location in Chromosome : 12q15

Description of this Gene: lysozyme

Type of Gene: protein-coding

rs1800973 in LYZ gene and Alcoholic Intoxication, Chronic PMID 19581569 2009 Genome-wide association study of alcohol dependence.

rs121913547 in LYZ gene and Amyloidosis, familial visceral PMID 8464497 1993 Human lysozyme gene mutations cause hereditary systemic amyloidosis.

rs1800973 in LYZ gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs1800973 in LYZ gene and Monocyte count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs1800973 in LYZ gene and Monocyte count result PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs1800973 in LYZ gene and Oral Ulcer PMID 30837455 2019 Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.

rs1800973 in LYZ gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.