Gene: MGMT

Alternate names for this Gene: -

Gene Summary: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.

Gene is located in Chromosome: 10

Location in Chromosome : 10q26.3

Description of this Gene: O-6-methylguanine-DNA methyltransferase

Type of Gene: protein-coding

rs2008387 in MGMT gene and Anorexia Nervosa PMID 31308545 2019 Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

rs4751108 in MGMT gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs80312298 in MGMT gene and Dermatitis, Atopic PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs80312298 in MGMT gene and Psoriasis PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs16906252 in MGMT gene and Smoking PMID 26183928 2015 Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

rs16906252 in MGMT gene and Smoking Behaviors PMID 26183928 2015 Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

rs11016883 in MGMT gene and Waist-Hip Ratio PMID 23192594 2013 Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.

rs477692 in MGMT gene and response to temozolomide PMID 23047291 2012 A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.