Gene: MOB4

Alternate names for this Gene: 2C4D|CGI-95|MOB1|MOB3|MOBKL3|PHOCN|PREI3

Gene Summary: This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.

Gene is located in Chromosome: 2

Location in Chromosome : 2q33.1

Description of this Gene: MOB family member 4, phocein

Type of Gene: protein-coding

Gene: HSPE1-MOB4

Alternate names for this Gene: HSPE1-PHOCN

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.

Gene is located in Chromosome: 2

Location in Chromosome : 2q33.1

Description of this Gene: HSPE1-MOB4 readthrough

Type of Gene: protein-coding

rs3792158 in MOB4;HSPE1-MOB4 gene and Allergic Reaction PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

rs10211550 in MOB4;HSPE1-MOB4 gene and Child Development Disorders, Pervasive PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs10211550 in MOB4;HSPE1-MOB4 gene and Schizophrenia PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.