Gene: MSMB

Alternate names for this Gene: HPC13|IGBF|MSP|MSPB|PN44|PRPS|PSP|PSP-94|PSP57|PSP94

Gene Summary: The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q11.22

Description of this Gene: microseminoprotein beta

Type of Gene: protein-coding

rs10993994 in MSMB gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs10993994 in MSMB gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10993994 in MSMB gene and Malignant neoplasm of prostate PMID 18264096 2008 Multiple loci identified in a genome-wide association study of prostate cancer.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 24753544 2014 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

PMID 20676098 2010 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.

rs10993994 in MSMB gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs10993994 in MSMB gene and Prostate carcinoma PMID 26443449 2015 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.

PMID 31562322 2019 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.

PMID 31226226 2020 A genome-wide association study of prostate cancer in Latinos.

PMID 20676098 2010 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.

PMID 18264096 2008 Multiple loci identified in a genome-wide association study of prostate cancer.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 24740154 2014 Genome-wide association scan for variants associated with early-onset prostate cancer.

PMID 24753544 2014 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

PMID 25939597 2015 Two susceptibility loci identified for prostate cancer aggressiveness.

PMID 26034056 2015 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

rs10993994 in MSMB gene and Prostate specific antigen measurement PMID 23269536 2013 Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.

PMID 21160077 2010 Overall, we detected a genome-wide significant association between PSA levels and single-nucleotide polymorphisms (SNPs) at six loci: 5p15.33 (rs2736098), 10q11 (rs10993994), 10q26 (rs10788160), 12q24 (rs11067228), 17q12 (rs4430796), and 19q13.33 [rs17632542 (KLK3: I179T)], each with P(combined) <3 × 10(-10).

PMID 28139693 2017 Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.