Gene: NPM1

Alternate names for this Gene: B23|NPM

Gene Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified.

Gene is located in Chromosome: 5

Location in Chromosome : 5q35.1

Description of this Gene: nucleophosmin 1

Type of Gene: protein-coding

rs1057519744 in NPM1 gene and Leukemia, Myelocytic, Acute PMID 19657110 2009 Recurring mutations found by sequencing an acute myeloid leukemia genome.

rs10040865 in NPM1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.