Gene: NPM3

Alternate names for this Gene: PORMIN|TMEM123

Gene Summary: The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: nucleophosmin/nucleoplasmin 3

Type of Gene: protein-coding

Gene: FGF8

Alternate names for this Gene: AIGF|FGF-8|HBGF-8|HH6|KAL6

Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: fibroblast growth factor 8

Type of Gene: protein-coding