Gene: NRG1

Alternate names for this Gene: ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF

Gene Summary: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Gene is located in Chromosome: 8

Location in Chromosome : 8p12

Description of this Gene: neuregulin 1

Type of Gene: protein-coding

rs4236709 in NRG1 gene and Adenocarcinoma of lung (disorder) PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

PMID 31326317 2019 Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

rs17673138 in NRG1 gene and Bipolar Disorder PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs7826312 in NRG1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2466103 in NRG1 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

rs4512342 in NRG1 gene and Childhood asthma PMID 17611496 2007 Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.

rs7820838 in NRG1 gene and Chronic Obstructive Airway Disease PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs1878918 in NRG1 gene and Cleft Palate PMID 28054174 2017 Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.

rs1878918 in NRG1 gene and Cleft upper lip PMID 28054174 2017 Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.

rs16879552 in NRG1 gene and Congenital Intestinal Aganglionosis PMID 19196962 2009 Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.

PMID 25310821 2014 A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease.

PMID 27702942 2016 Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease.

rs6996585 in NRG1 gene and Differentiated Thyroid Gland Carcinoma PMID 28703219 2017 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer.

rs10102889 in NRG1 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

PMID 31015462 2019 Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.

PMID 30604766 2019 Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

rs10954843 in NRG1 gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs16879552 in NRG1 gene and Hirschsprung Disease PMID 19196962 2009 Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.

PMID 25310821 2014 A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease.

PMID 27702942 2016 Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease.

rs7825175 in NRG1 gene and Hormone measurement PMID 23408906 2013 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

rs2466075 in NRG1 gene and Hypothyroidism PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs17673138 in NRG1 gene and Major Depressive Disorder PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs4236709 in NRG1 gene and Non-Small Cell Lung Carcinoma PMID 31326317 2019 Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

rs10088648 in NRG1 gene and Oral cleft PMID 28054174 2017 Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.

rs6996585 in NRG1 gene and Papillary thyroid carcinoma PMID 28703219 2017 Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer.

rs77752517 in NRG1 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17673138 in NRG1 gene and Schizophrenia PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs10954843 in NRG1 gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs16879344 in NRG1 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs200393053 in NRG1 gene and Stem Cell Factor Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs527953512 in NRG1 gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs2439302 in NRG1 gene and Thyroid carcinoma PMID 22267200 2012 After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer.

PMID 28195142 2017 A genome-wide association study yields five novel thyroid cancer risk loci.

rs7825175 in NRG1 gene and Thyroid stimulating hormone measurement PMID 23408906 2013 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

rs17673138 in NRG1 gene and Unipolar Depression PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs2466077 in NRG1 gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

rs35033136 in NRG1 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7820838 in NRG1 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.