Gene: NUP37

Alternate names for this Gene: MCPH24|p37

Gene Summary: Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis.

Gene is located in Chromosome: 12

Location in Chromosome : 12q23.2

Description of this Gene: nucleoporin 37

Type of Gene: protein-coding

rs2271266 in NUP37 gene and Body Height PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs746341112 in NUP37 gene and MICROCEPHALY 24, PRIMARY, AUTOSOMAL RECESSIVE PMID 30179222 2018 Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome.

rs12425639 in NUP37 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.