Gene: OTUB2

Alternate names for this Gene: C14orf137|OTB2|OTU2

Gene Summary: This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.

Gene is located in Chromosome: 14

Location in Chromosome : 14q32.12

Description of this Gene: OTU deubiquitinase, ubiquitin aldehyde binding 2

Type of Gene: protein-coding

rs181157443 in OTUB2 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs10131610 in OTUB2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.