Gene: PBX2

Alternate names for this Gene: G17|HOX12|PBX2MHC

Gene Summary: This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: PBX homeobox 2

Type of Gene: protein-coding

Gene: GPSM3

Alternate names for this Gene: AGS4|C6orf9|G18|G18.1a|G18.1b|G18.2|NG1

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: G protein signaling modulator 3

Type of Gene: protein-coding

rs176095 in PBX2;GPSM3 gene and Allergic Reaction PMID 23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

rs176095 in PBX2;GPSM3 gene and Dermatitis, Atopic PMID 23042114 2012 Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.

PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs176095 in PBX2;GPSM3 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.