Gene: PCDH9

Alternate names for this Gene: -

Gene Summary: This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 13

Location in Chromosome : 13q21.32

Description of this Gene: protocadherin 9

Type of Gene: protein-coding

rs9529199 in PCDH9 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs1927820 in PCDH9 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs77691144 in PCDH9 gene and Child Development Disorders, Pervasive PMID 30804558 2019 Identification of common genetic risk variants for autism spectrum disorder.

rs9599114 in PCDH9 gene and Chronic Obstructive Airway Disease PMID 29631575 2018 The genetics of smoking in individuals with chronic obstructive pulmonary disease.

rs913493 in PCDH9 gene and Liver carcinoma PMID 30945699 2019 Genome-Wide Association Study Identifies a Genetic Prediction Model for Postoperative Survival in Patients with Hepatocellular Carcinoma.

PMID 30945673 2019 Genomewide association study for C-reactive protein in Indians replicates known associations of common variants.

rs1413573 in PCDH9 gene and Major Depressive Disorder PMID 29728651 2018 Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.

PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

PMID 27479909 2016 Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.

PMID 30718901 2019 Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

rs17081231 in PCDH9 gene and Obesity PMID 21552555 2011 A genome-wide association study on obesity and obesity-related traits.

rs7319172 in PCDH9 gene and Potassium measurement PMID 31409800 2019 GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.

rs9529199 in PCDH9 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs9571576 in PCDH9 gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

rs9529055 in PCDH9 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.