Gene: PDE3A

Alternate names for this Gene: CGI-PDE|CGI-PDE A|CGI-PDE-A|HTNB

Gene Summary: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene is located in Chromosome: 12

Location in Chromosome : 12p12.2

Description of this Gene: phosphodiesterase 3A

Type of Gene: protein-coding

rs10841530 in PDE3A gene and Alcohol consumption PMID 24376456 2013 Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.

rs10770700 in PDE3A gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

PMID 29782485 2018 Evaluation and application of summary statistic imputation to discover new height-associated loci.

rs7304841 in PDE3A gene and Cerebrovascular accident PMID 29531354 2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

rs10047560 in PDE3A gene and Diabetic Nephropathy PMID 21150874 2011 A genome-wide association study for diabetic nephropathy genes in African Americans.

rs7137534 in PDE3A gene and Height PMID 21194676 2011 Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

rs7313422 in PDE3A gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs7304841 in PDE3A gene and Ischemic stroke PMID 29531354 2018 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

rs7310698 in PDE3A gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs10841496 in PDE3A gene and Male infertility PMID 19478329 2010 Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia.

rs1348582 in PDE3A gene and QT interval feature (observable entity) PMID 20031603 2009 A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

rs7313422 in PDE3A gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs10841530 in PDE3A gene and Systolic Pressure PMID 24376456 2013 Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs8181710 in PDE3A gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs11045235 in PDE3A gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.