Gene: PER2

Alternate names for this Gene: FASPS|FASPS1

Gene Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.3

Description of this Gene: period circadian regulator 2

Type of Gene: protein-coding

rs121908635 in PER2 gene and ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 1 PMID 11232563 2001 An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.

rs74508725 in PER2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs35333999 in PER2 gene and Circadian Rhythms PMID 26955885 2016 Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.