Gene: PGA5

Alternate names for this Gene: Pg5

Gene Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.2

Description of this Gene: pepsinogen A5

Type of Gene: protein-coding