Gene: POSTN

Alternate names for this Gene: OSF-2|OSF2|PDLPOSTN|PN

Gene Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 13

Location in Chromosome : 13q13.3

Description of this Gene: periostin

Type of Gene: protein-coding