Gene: PPP2R1B

Alternate names for this Gene: PP2A-Abeta|PR65B

Gene Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.1

Description of this Gene: protein phosphatase 2 scaffold subunit Abeta

Type of Gene: protein-coding

Gene: SIK2

Alternate names for this Gene: LOH11CR1I|QIK|SIK-2|SNF1LK2

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.1

Description of this Gene: salt inducible kinase 2

Type of Gene: protein-coding

rs7937682 in PPP2R1B;SIK2 gene and Cholangitis, Sclerosing PMID 23603763 2013 Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

PMID 27992413 2017 Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

rs12362593 in PPP2R1B;SIK2 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs7937682 in PPP2R1B;SIK2 gene and Primary sclerosing cholangitis PMID 23603763 2013 Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

rs17565975 in PPP2R1B;SIK2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.