Gene: PPP4R4

Alternate names for this Gene: CFAP14|KIAA1622|PP4R4

Gene Summary: The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm.

Gene is located in Chromosome: 14

Location in Chromosome : 14q32.12-q32.13

Description of this Gene: protein phosphatase 4 regulatory subunit 4

Type of Gene: protein-coding

rs11160165 in PPP4R4 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs112458284 in PPP4R4 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs112458284 in PPP4R4 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.