Gene: PPT2

Alternate names for this Gene: C6orf8|G14|PPT-2

Gene Summary: This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: palmitoyl-protein thioesterase 2

Type of Gene: protein-coding

Gene: EGFL8

Alternate names for this Gene: C6orf8|NG3

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: EGF like domain multiple 8

Type of Gene: protein-coding

Gene: AGPAT1

Alternate names for this Gene: 1-AGPAT1|G15|LPAAT-alpha|LPAATA

Gene Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: 1-acylglycerol-3-phosphate O-acyltransferase 1

Type of Gene: protein-coding

Gene: PPT2-EGFL8

Alternate names for this Gene: PPT-2|PPT2

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring PPT2 (palmitoyl-protein thioesterase 2) and EGFL8 (EGF-like-domain, multiple 8) genes located in the major histocompatibility complex class III region of chromosome 6. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: PPT2-EGFL8 readthrough (NMD candidate)

Type of Gene: ncRNA

rs1061808 in PPT2;EGFL8;AGPAT1;PPT2-EGFL8 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs1061808 in PPT2;EGFL8;AGPAT1;PPT2-EGFL8 gene and Phospholipid measurement PMID 22359512 2012 Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.