Gene: PRKG2

Alternate names for this Gene: PKG2|PRKGR2|cGK2|cGKII

Gene Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.21

Description of this Gene: protein kinase cGMP-dependent 2

Type of Gene: protein-coding

rs41332544 in PRKG2 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs3822224 in PRKG2 gene and Body Height PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs984924 in PRKG2 gene and Brain Waves PMID 29947131 2018 Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.

rs710839 in PRKG2 gene and Height PMID 21998595 2011 Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

rs41332544 in PRKG2 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs17484474 in PRKG2 gene and Systolic Pressure PMID 25189868 2015 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.