Gene: PSORS1C2

Alternate names for this Gene: C6orf17|SPR1

Gene Summary:

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: psoriasis susceptibility 1 candidate 2

Type of Gene: protein-coding

Gene: PSORS1C1

Alternate names for this Gene: C6orf16|SEEK1

Gene Summary: This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: psoriasis susceptibility 1 candidate 1

Type of Gene: protein-coding

rs149979052 in PSORS1C2;PSORS1C1 gene and Child Development Disorders, Pervasive PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs2285803 in PSORS1C2;PSORS1C1 gene and Multiple Myeloma PMID 23955597 2013 Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

rs1966 in PSORS1C2;PSORS1C1 gene and Rheumatoid Arthritis PMID 17804836 2007 TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

rs149979052 in PSORS1C2;PSORS1C1 gene and Schizophrenia PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

rs3130573 in PSORS1C2;PSORS1C1 gene and Systemic Scleroderma PMID 21750679 2011 Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.

rs1265091 in PSORS1C2;PSORS1C1 gene and Thyroid stimulating hormone measurement PMID 30367059 2018 Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.