Gene: QPCT

Alternate names for this Gene: GCT|QC|sQC

Gene Summary: This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Gene is located in Chromosome: 2

Location in Chromosome : 2p22.2

Description of this Gene: glutaminyl-peptide cyclotransferase

Type of Gene: protein-coding

rs3770745 in QPCT gene and Chronic Lymphocytic Leukemia PMID 23770605 2013 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

PMID 26956414 2016 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

rs2373000 in QPCT gene and Schizophrenia PMID 23974872 2013 Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

rs3770745 in QPCT gene and Small Lymphocytic Lymphoma PMID 26956414 2016 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.