Gene: RAD18

Alternate names for this Gene: RNF73

Gene Summary: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Gene is located in Chromosome: 3

Location in Chromosome : 3p25.3

Description of this Gene: RAD18 E3 ubiquitin protein ligase

Type of Gene: protein-coding