Gene: RAD51

Alternate names for this Gene: BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA

Gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 15

Location in Chromosome : 15q15.1

Description of this Gene: RAD51 recombinase

Type of Gene: protein-coding

rs11855560 in RAD51 gene and Anxiety Disorders PMID 31116379 2019 Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.

rs1057519413 in RAD51 gene and Dysmorphic features PMID 25813273 2015 Congenital mirror movements: phenotypes associated with DCC and RAD51 mutations.

PMID 26253028 2015 A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.

PMID 24808016 2014 Congenital mirror movements: mutational analysis of RAD51 and DCC in 26 cases.

rs199925463 in RAD51 gene and MIRROR MOVEMENTS 2 PMID 21242494 2011 A novel DCC mutation and genetic heterogeneity in congenital mirror movements.

rs121917739 in RAD51 gene and Malignant neoplasm of breast PMID 17508274 2007 Risk assessment and genetic counseling for hereditary breast and ovarian cancer: recommendations of the National Society of Genetic Counselors.

PMID 25539919 2015 Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.

PMID 15604628 2004 Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors.

PMID 24366376 2014 Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement.

PMID 24366402 2014 Summaries for patients. Assessing the genetic risk for BRCA-related breast or ovarian cancer in women: recommendations from the U.S. Preventive Services Task Force.

PMID 10807537 2000 Identification of Rad51 alteration in patients with bilateral breast cancer.

PMID 18163131 2008 The emerging landscape of breast cancer susceptibility.

rs2928140 in RAD51 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.