Gene: RGS3

Alternate names for this Gene: C2PA|RGP3

Gene Summary: This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.

Gene is located in Chromosome: 9

Location in Chromosome : 9q32

Description of this Gene: regulator of G protein signaling 3

Type of Gene: protein-coding

rs113800797 in RGS3 gene and Body Height PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs12341266 in RGS3 gene and Hypertrophic Cardiomyopathy PMID 23255317 2013 Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy.

rs10981835 in RGS3 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs111296842 in RGS3 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.