Gene: RICTOR

Alternate names for this Gene: AVO3|PIA|hAVO3

Gene Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 5

Location in Chromosome : 5p13.1

Description of this Gene: RPTOR independent companion of MTOR complex 2

Type of Gene: protein-coding

rs1554059320 in RICTOR gene and Movement Disorders PMID 15284851 2004 Nonsense-mediated decay approaches the clinic.

PMID 25348405 2015 UniProt: a hub for protein information.

PMID 8751724 1996 Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver.

PMID 22500797 2012 mTOR signaling in growth control and disease.

PMID 16962829 2006 Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

PMID 17141160 2006 Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

PMID 23049074 2013 Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.

PMID 22521878 2012 Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

PMID 2006 1976 Nutrition education in the medical school curriculum: a proposal for action: a curriculum design.

PMID 11042116 2000 Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase.

PMID 19344873 2009 DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.

rs2043112 in RICTOR gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.