Gene: ROR1

Alternate names for this Gene: NTRKR1|dJ537F10.1

Gene Summary: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.3

Description of this Gene: receptor tyrosine kinase like orphan receptor 1

Type of Gene: protein-coding

rs12135035 in ROR1 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs1553163562 in ROR1 gene and DEAFNESS, AUTOSOMAL RECESSIVE 108 PMID 27162350 2016 ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.

rs10889450 in ROR1 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.