Gene: RSPO3

Alternate names for this Gene: CRISTIN1|PWTSR|THSD2

Gene Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.

Gene is located in Chromosome: 6

Location in Chromosome : 6q22.33

Description of this Gene: R-spondin 3

Type of Gene: protein-coding

Gene: LOC112267972

Alternate names for this Gene:

Gene Summary:

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rs10457487 in RSPO3;LOC112267972 gene and Bone Density PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs6569474 in RSPO3;LOC112267972 gene and Serum albumin measurement PMID 21909109 2011 Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

rs6569474 in RSPO3;LOC112267972 gene and Uric acid measurement (procedure) PMID 21909109 2011 Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

rs7745274 in RSPO3;LOC112267972 gene and Waist-Hip Ratio PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.