Gene: SELENOH

Alternate names for this Gene: C11orf31|C17orf10|SELH

Gene Summary: This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.1

Description of this Gene: selenoprotein H

Type of Gene: protein-coding

Gene: TMX2-CTNND1

Alternate names for this Gene: CAS|CTNND1|p120(cas)|p120(ctn)

Gene Summary: This locus represents naturally occurring read-through transcription between the neighboring TMX2 (thioredoxin-related transmembrane protein 2) and CTNND1 (catenin, cadherin-associated protein, delta 1) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product.

Gene is located in Chromosome: 11

Location in Chromosome : 11q12.1

Description of this Gene: TMX2-CTNND1 readthrough (NMD candidate)

Type of Gene: ncRNA