Gene: SFRP1

Alternate names for this Gene: FRP|FRP-1|FRP1|FrzA|SARP2

Gene Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.

Gene is located in Chromosome: 8

Location in Chromosome : 8p11.21

Description of this Gene: secreted frizzled related protein 1

Type of Gene: protein-coding

rs3055861 in SFRP1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs72643819 in SFRP1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11774662 in SFRP1 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.