Gene: SIGLEC5

Alternate names for this Gene: CD170|CD33L2|OB-BP2|OBBP2|SIGLEC-5

Gene Summary: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.41

Description of this Gene: sialic acid binding Ig like lectin 5

Type of Gene: protein-coding

rs4284742 in SIGLEC5 gene and Aggressive Periodontitis PMID 28449029 2017 A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.

rs1106476 in SIGLEC5 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs11084096 in SIGLEC5 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs10414149 in SIGLEC5 gene and Leprosy PMID 25642632 2015 Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

rs34312547 in SIGLEC5 gene and Lymphocyte Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11084095 in SIGLEC5 gene and Periodontitis PMID 30218097 2019 Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.

rs11084095 in SIGLEC5 gene and Periodontosis PMID 30218097 2019 Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.