Gene: SLC13A3

Alternate names for this Gene: ARLIAK|NADC3|SDCT2

Gene Summary: Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.12

Description of this Gene: solute carrier family 13 member 3

Type of Gene: protein-coding

rs847058 in SLC13A3 gene and Arthritis, Gouty PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs6066043 in SLC13A3 gene and Chronic Kidney Diseases PMID 24351856 2014 An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.

rs6066043 in SLC13A3 gene and Glomerular Filtration Rate PMID 24351856 2014 An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.

rs847058 in SLC13A3 gene and Gout PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs6066043 in SLC13A3 gene and Kidney Failure, Chronic PMID 24351856 2014 An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.

rs2757524 in SLC13A3 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.