Gene: SLC18A2

Alternate names for this Gene: PKDYS2|SVAT|SVMT|VAT2|VMAT2

Gene Summary: This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments.

Gene is located in Chromosome: 10

Location in Chromosome : 10q25.3

Description of this Gene: solute carrier family 18 member A2

Type of Gene: protein-coding

rs1293033867 in SLC18A2 gene and Muscle hypotonia PMID 26539891 2015 Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease.

PMID 23911319 2013 Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network.

PMID 26497564 2016 Brain dopamine-serotonin vesicular transport disease presenting as a severe infantile hypotonic parkinsonian disorder.

PMID 23363473 2013 Brain dopamine-serotonin vesicular transport disease and its treatment.

rs363271 in SLC18A2 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs1392638187 in SLC18A2 gene and PARKINSONISM-DYSTONIA, INFANTILE, 2 PMID 23363473 2013 Brain dopamine-serotonin vesicular transport disease and its treatment.