Gene: SLC24A2

Alternate names for this Gene: NCKX2

Gene Summary: This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 9

Location in Chromosome : 9p22.1-p21.3

Description of this Gene: solute carrier family 24 member 2

Type of Gene: protein-coding

rs7870850 in SLC24A2 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs4977397 in SLC24A2 gene and Atrial Fibrillation PMID 29892015 2018 Multi-ethnic genome-wide association study for atrial fibrillation.

rs6475417 in SLC24A2 gene and Mood Disorders PMID 30116032 2018 Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.

rs7870850 in SLC24A2 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs117322666 in SLC24A2 gene and Serum gamma-glutamyl transferase measurement PMID 30589442 2019 Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.

rs6475417 in SLC24A2 gene and Suicide attempt PMID 30116032 2018 Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.

rs10964221 in SLC24A2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.