Gene: SMG1

Alternate names for this Gene: 61E3.4|ATX|LIP

Gene Summary: This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.3

Description of this Gene: SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Type of Gene: protein-coding

rs735173 in SMG1 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

rs2650618 in SMG1 gene and Schizophrenia PMID 21926974 2011 Genome-wide association study identifies five new schizophrenia loci.