Gene: SORCS2

Alternate names for this Gene: -

Gene Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system.

Gene is located in Chromosome: 4

Location in Chromosome : 4p16.1

Description of this Gene: sortilin related VPS10 domain containing receptor 2

Type of Gene: protein-coding

rs6446592 in SORCS2 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs11731003 in SORCS2 gene and Alcohol withdrawal syndrome PMID 30252935 2018 Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

rs4234795 in SORCS2 gene and Anemia, Sickle Cell PMID 28552477 2017 Genome-wide association study of erythrocyte density in sickle cell disease patients.

rs13125782 in SORCS2 gene and Anorexia Nervosa PMID 28494655 2017 Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.

rs4689642 in SORCS2 gene and Attention deficit hyperactivity disorder PMID 26174813 2015 New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.

rs35791045 in SORCS2 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs111913416 in SORCS2 gene and Interleukin 10 Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs10002854 in SORCS2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs17828052 in SORCS2 gene and Myocardial Infarction PMID 21211798 2011 Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.

rs6446592 in SORCS2 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs11931821 in SORCS2 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs73214671 in SORCS2 gene and Transferrin saturation measurement PMID 28334935 2017 Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?