Gene: SPOCK1

Alternate names for this Gene: SPOCK|TESTICAN|TIC1

Gene Summary: This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.2

Description of this Gene: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

Type of Gene: protein-coding

rs2348186 in SPOCK1 gene and Age at menarche PMID 19282985 2009 Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche.

rs143404520 in SPOCK1 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs79987496 in SPOCK1 gene and Smoking PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs79987496 in SPOCK1 gene and Smoking Behaviors PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

rs11743006 in SPOCK1 gene and mathematical ability PMID 28155865 2017 A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability.

rs2349007 in SPOCK1 gene and response to ACE inhibitor PMID 28084903 2017 Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.