Gene: ST6GAL1

Alternate names for this Gene: SIAT1|ST6GalI|ST6N

Gene Summary: This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3q27.3

Description of this Gene: ST6 beta-galactoside alpha-2,6-sialyltransferase 1

Type of Gene: protein-coding

rs16861384 in ST6GAL1 gene and Adiponectin Measurement PMID 20887962 2010 Adiponectin concentrations: a genome-wide association study.

rs3936289 in ST6GAL1 gene and Alzheimer's Disease PMID 28560309 2017 Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.

rs3864106 in ST6GAL1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs10937275 in ST6GAL1 gene and Chemical and Drug Induced Liver Injury PMID 19483685 2009 HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.

rs16861329 in ST6GAL1 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 23300278 2013 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

PMID 21874001 2011 Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.

PMID 30054458 2018 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2239612 in ST6GAL1 gene and Esophageal Neoplasms PMID 22960999 2012 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

rs7634389 in ST6GAL1 gene and IGA Glomerulonephritis PMID 26028593 2015 Identification of new susceptibility loci for IgA nephropathy in Han Chinese.

rs3936289 in ST6GAL1 gene and Impaired cognition PMID 28560309 2017 Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.

rs17374323 in ST6GAL1 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs2239612 in ST6GAL1 gene and Squamous cell carcinoma PMID 22960999 2012 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

rs4012172 in ST6GAL1 gene and Thyroglobulin measurement PMID 30929638 2019 The lead SNP was rs4012172 ( documentclass{aastex}usepackage{amsbsy}usepackage{amsfonts}usepackage{amssymb}usepackage{bm}usepackage{mathrsfs}usepackage{pifont}usepackage{stmaryrd}usepackage{textcomp}usepackage{portland, xspace}usepackage{amsmath, amsxtra}usepackage{upgreek}pagestyle{empty}DeclareMathSizes{10}{9}{7}{6}egin{document} $$p = 1.29 imes {10^{ - 10}}$$ end{document} ), which explained 3.19% of the variance in Tg levels.