Gene: SUCLG2

Alternate names for this Gene: G-SCS|GBETA|GTPSCS

Gene Summary: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.1

Description of this Gene: succinate-CoA ligase GDP-forming subunit beta

Type of Gene: protein-coding

rs62256378 in SUCLG2 gene and Alzheimer's Disease PMID 25027320 2014 Clinically, rs62256378 was associated with rate of cognitive decline in AD dementia patients (P = 3.1 × 10(-3)).

rs115560420 in SUCLG2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs115560420 in SUCLG2 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4132748 in SUCLG2 gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs17806888 in SUCLG2 gene and Height PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs11923377 in SUCLG2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs76010824 in SUCLG2 gene and Prostate carcinoma PMID 26307654 2015 Genome-wide association study of prostate cancer-specific survival.

rs1490265 in SUCLG2 gene and Vital capacity PMID 28166213 2017 Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.