Gene: TNF

Alternate names for this Gene: DIF|TNF-alpha|TNFA|TNFSF2|TNLG1F

Gene Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: tumor necrosis factor

Type of Gene: protein-coding

rs3093661 in TNF gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs3093661 in TNF gene and AIDS, PROGRESSION TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs3093662 in TNF gene and Acquired Immunodeficiency Syndrome PMID 19115949 2009 Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).

rs3093664 in TNF gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs1800610 in TNF gene and Graves Disease PMID 21900946 2011 Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.

rs3093661 in TNF gene and HIV-1, RESISTANCE TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs3093661 in TNF gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

rs3093662 in TNF gene and Rheumatoid Arthritis PMID 17804836 2007 TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.