Gene: TNFRSF9

Alternate names for this Gene: 4-1BB|CD137|CDw137|ILA

Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.23

Description of this Gene: TNF receptor superfamily member 9

Type of Gene: protein-coding

rs34878017 in TNFRSF9 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs9657955 in TNFRSF9 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs201395463 in TNFRSF9 gene and Waist-Hip Ratio PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.