Gene: TNFSF12

Alternate names for this Gene: APO3L|DR3LG|TNLG4A|TWEAK

Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.1

Description of this Gene: TNF superfamily member 12

Type of Gene: protein-coding

Gene: TNFSF12-TNFSF13

Alternate names for this Gene: TWE-PRIL

Gene Summary: This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines.

Gene is located in Chromosome: 17

Location in Chromosome : 17p13.1

Description of this Gene: TNFSF12-TNFSF13 readthrough

Type of Gene: protein-coding