Gene: TOP1

Alternate names for this Gene: TOPI

Gene Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

Gene is located in Chromosome: 20

Location in Chromosome : 20q12

Description of this Gene: DNA topoisomerase I

Type of Gene: protein-coding

Gene: PLCG1-AS1

Alternate names for this Gene:

Gene Summary:

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rs16989541 in TOP1;PLCG1-AS1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6072275 in TOP1;PLCG1-AS1 gene and Fasting blood glucose measurement PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs6072275 in TOP1;PLCG1-AS1 gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs73611258 in TOP1;PLCG1-AS1 gene and Uric acid measurement (procedure) PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.