Gene: TRIM5

Alternate names for this Gene: RNF88|TRIM5alpha

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: tripartite motif containing 5

Type of Gene: protein-coding

Gene: TRIM6

Alternate names for this Gene: RNF89

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: tripartite motif containing 6

Type of Gene: protein-coding

Gene: TRIM6-TRIM34

Alternate names for this Gene: IFP1|RNF21|RNF89|TRIM34|TRIM6

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: TRIM6-TRIM34 readthrough

Type of Gene: protein-coding

rs3751006 in TRIM5;TRIM6;TRIM6-TRIM34 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7120093 in TRIM5;TRIM6;TRIM6-TRIM34 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.